PUBLICATIONS

  • Arena, D. T., & Hofer, A. M. (2022). Imaging the cAMP signaling microdomain of the primary cilium using targeted FRET-based biosensors. Methods Mol Biol. 2483:77-92. doi: 10.1007/978-1-0716-2245-2_5.
  • Hofer, A.M. (2021). Perspective: The love story between Orai calcium entry channels and adenylyl cyclases gets even more complicated. Function (Oxf). 2(5):zqab044. doi: 10.1093/function/zqab044.
  • Kitamura, Y., Kanaya, N., Moleirinho, S., Du, W., Reinshagen, C., Attia, N., Bronisz, A., Revai-Lechtich, E., Sasaki, H., Mora, J.L., Kaliopi-Brastianos, P., Falcone, J.L., Hofer, A.M., Franco, A., and Shah, K. (2021). Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Science Advances, 7(10). doi:10.1126/sciadv.abe8671.
  • Arena, D. T., & Hofer, A. M. (2021). Cyclic AMP does double duty to support parallel signaling in primary cilium and cytosol. Cell Calcium, 97, 102436. doi:10.1016/j.ceca.2021.102436
  • Ambudkar, I.S. and Hofer A.M. (2020) Calcium Signaling. Current Opinion in Physiology. 17, iii-iv. doi: 10.1016/j.cophys.2020.11.005
  • Jiang, J. Y., Falcone, J. L., Curci, S., & Hofer, A. M. (2019). Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation. Proc Natl Acad Sci U S A, 116(24), 12066-12071. doi:10.1073/pnas.1819730116
  • Kuo, I. Y., Brill, A. L., Lemos, F. O., Jiang, J. Y., Falcone, J. L., Kimmerling, E. P., Kaplan, D.L., Wallace, D.P., Hofer, A.M., Ehrlich, B. E. (2019). Polycystin 2 regulates mitochondrial Ca(2+) signaling, bioenergetics, and dynamics through mitofusin 2. Sci Signal, 12(580). doi:10.1126/scisignal.aat7397
  • Hofer, A. M. (2019). cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai. Cell Calcium, 82, 102054. doi:10.1016/j.ceca.2019.102054
  • Jiang, J. Y., Falcone, J. L., Curci, S., & Hofer, A. M. (2017). Interrogating cyclic AMP signaling using optical approaches. Cell Calcium, 64, 47-56. doi:10.1016/j.ceca.2017.02.010
  • Colella, M., Gerbino, A., Hofer, A. M., & Curci, S. (2016). Recent advances in understanding the extracellular calcium-sensing receptor. F1000Res, 5. doi:10.12688/f1000research.8963.1
  • Nichols, J. M., Maiellaro, I., Abi-Jaoude, J., Curci, S., & Hofer, A. M. (2015). “Store-operated” cAMP signaling contributes to Ca2+-activated Cl- secretion in T84 colonic cells. Am J Physiol Gastrointest Liver Physiol, 309(8), G670-679. doi:10.1152/ajpgi.00214.2015
  • Hofer, A. M. (2015). Ca²⁺ signaling at membrane contact sites. Cell Calcium, 58(4), 331-332. doi:10.1016/j.ceca.2015.07.002
  • Lefkimmiatis, K., Leronni, D., & Hofer, A. M. (2013). The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics. J Cell Biol, 202(3), 453-462. doi:10.1083/jcb.201303159
  • Cardone, A., Lopez, F., Affortunato, F., Busco, G., Hofer, A. M., Mallamaci, R., . . . Farinola, G. M. (2012). An aryleneethynylene fluorophore for cell membrane staining. Biochim Biophys Acta, 1818(11), 2808-2817. doi:10.1016/j.bbamem.2012.06.011
  • Maiellaro, I., Lefkimmiatis, K., Moyer, M. P., Curci, S., & Hofer, A. M. (2012). Termination and activation of store-operated cyclic AMP production. J Cell Mol Med, 16(11), 2715-2725. doi:10.1111/j.1582-4934.2012.01592.x
  • Hofer, A. M. (2012). Interactions between calcium and cAMP signaling. Curr Med Chem, 19(34), 5768-5773. doi:10.2174/092986712804143286
  • Murakami, T., Ockinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012). Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A, 109(28), 11282-11287. doi:10.1073/pnas.1117765109
  • Schwarzer, C., Wong, S., Shi, J., Matthes, E., Illek, B., Ianowski, J. P., . . . Machen, T. E. (2010). Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia. J Biol Chem, 285(45), 34850-34863. doi:10.1074/jbc.M110.167668
  • Roy, J., Lefkimmiatis, K., Moyer, M. P., Curci, S., & Hofer, A. M. (2010). The {omega}-3 fatty acid eicosapentaenoic acid elicits cAMP generation in colonic epithelial cells via a “store-operated” mechanism. Am J Physiol Gastrointest Liver Physiol, 299(3), G715-722. doi:10.1152/ajpgi.00028.2010
  • Lefkimmiatis, K., Srikanthan, M., Maiellaro, I., Moyer, M. P., Curci, S., & Hofer, A. M. (2009). Store-operated cyclic AMP signalling mediated by STIM1. Nat Cell Biol, 11(4), 433-442. doi:10.1038/ncb1850
  • Lefkimmiatis, K., Moyer, M. P., Curci, S., & Hofer, A. M. (2009). “cAMP sponge”: a buffer for cyclic adenosine 3′, 5′-monophosphate. PLoS One, 4(11), e7649. doi:10.1371/journal.pone.0007649
  • Gerbino, A., Fistetto, G., Colella, M., Hofer, A. M., Debellis, L., Caroppo, R., & Curci, S. (2007). Real time measurements of water flow in amphibian gastric glands: modulation via the extracellular Ca2+-sensing receptor. J Biol Chem, 282(18), 13477-13486. doi:10.1074/jbc.M610585200
  • Hofer, A. M. (2007). Review series on the extracellular Ca(2+)-sensing receptor. J Cell Mol Med, 11(5), 906-907. doi:10.1111/j.1582-4934.2007.00116.x
  • Zou, J., Hofer, A. M., Lurtz, M. M., Gadda, G., Ellis, A. L., Chen, N., . . . Yang, J. J. (2007). Developing sensors for real-time measurement of high Ca2+ concentrations. Biochemistry, 46(43), 12275-12288. doi:10.1021/bi7007307
  • Hofer, A. M., & Lefkimmiatis, K. (2007). Extracellular calcium and cAMP: second messengers as “third messengers”? Physiology (Bethesda), 22, 320-327. doi:10.1152/physiol.00019.2007
  • Hofer, A. M. (2006). Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol, 312, 229-247.
  • Hofer, A. M. (2005). Measurement of free [Ca²+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol, 312, 229-247. doi:10.1385/1-59259-949-4:229
  • Lau, B. W., Colella, M., Ruder, W. C., Ranieri, M., Curci, S., & Hofer, A. M. (2005). Deoxycholic acid activates protein kinase C and phospholipase C via increased Ca2+ entry at plasma membrane. Gastroenterology, 128(3), 695-707. doi:10.1053/j.gastro.2004.12.046
  • Gerbino, A., Ruder, W. C., Curci, S., Pozzan, T., Zaccolo, M., & Hofer, A. M. (2005). Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. J Cell Biol, 171(2), 303-312. doi:10.1083/jcb.200507054
  • Hofer, A. M. (2005). Another dimension to calcium signaling: a look at extracellular calcium. J Cell Sci, 118(Pt 5), 855-862. doi:10.1242/jcs.01705
  • Gerbino, A., Hofer, A. M., McKay, B., Lau, B. W., & Soybel, D. I. (2004). Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells. Gastroenterology, 126(1), 182-195. doi:10.1053/j.gastro.2003.10.068
  • Caroppo, R., Gerbino, A., Fistetto, G., Colella, M., Debellis, L., Hofer, A. M., & Curci, S. (2004). Extracellular calcium acts as a “third messenger” to regulate enzyme and alkaline secretion. J Cell Biol, 166(1), 111-119. doi:10.1083/jcb.200310145
  • Hofer, A. M., Gerbino, A., Caroppo, R., & Curci, S. (2004). The extracellular calcium-sensing receptor and cell-cell signaling in epithelia. Cell Calcium, 35(3), 297-306. doi:10.1016/j.ceca.2003.10.021
  • De Luisi, A., & Hofer, A. M. (2003). Evidence that Ca(2+) cycling by the plasma membrane Ca(2+)-ATPase increases the ‘excitability’ of the extracellular Ca(2+)-sensing receptor. J Cell Sci, 116(Pt 8), 1527-1538. doi:10.1242/jcs.00368
  • Caroppo, R., Colella, M., Colasuonno, A., DeLuisi, A., Debellis, L., Curci, S., & Hofer, A. M. (2003). A reassessment of the effects of luminal [Ca2+] on inositol 1,4,5-trisphosphate-induced Ca2+ release from internal stores. J Biol Chem, 278(41), 39503-39508. doi:10.1074/jbc.M305823200
  • Hofer, A. M., & Brown, E. M. (2003). Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol, 4(7), 530-538. doi:10.1038/nrm1154
  • Caroppo, R., Gerbino, A., Debellis, L., Kifor, O., Soybel, D. I., Brown, E. M., . . . Curci, S. (2001). Asymmetrical, agonist-induced fluctuations in local extracellular [Ca(2+)] in intact polarized epithelia. EMBO J., 20(22), 6316-6326. doi:10.1093/emboj/20.22.6316
  • Hofer, A. M., Curci, S., Doble, M. A., Brown, E. M., & Soybel, D. I. (2000). Intercellular communication mediated by the extracellular calcium-sensing receptor. Nat Cell Biol, 2(7), 392-398. doi:10.1038/35017020
  • Hofer, A. M. (1999). Measurement of free [Ca2+] changes in agonist-sensitive internal stores using compartmentalized fluorescent indicators. Methods Mol Biol, 114, 249-265. doi:10.1385/1-59259-250-3:249
  • Hofer, A. M., Fasolato, C., & Pozzan, T. (1998). Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]. J Cell Biol, 140(2), 325-334. doi:10.1083/jcb.140.2.325
  • Hofer, A. M., Landolfi, B., Debellis, L., Pozzan, T., & Curci, S. (1998). Free [Ca2+] dynamics measured in agonist-sensitive stores of single living intact cells: a new look at the refilling process. EMBO J., 17(7), 1986-1995. doi:10.1093/emboj/17.7.1986
  • Landolfi, B., Curci, S., Debellis, L., Pozzan, T., & Hofer, A. M. (1998). Ca2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells. J Cell Biol, 142(5), 1235-1243. doi:10.1083/jcb.142.5.1235
  • Hofer, A. M., & Schulz, I. (1996). Quantification of intraluminal free [Ca] in the agonist-sensitive internal calcium store using compartmentalized fluorescent indicators: some considerations. Cell Calcium, 20(3), 235-242. doi:10.1016/s0143-4160(96)90029-9
  • Hofer, A. M., Curci, S., Machen, T. E., & Schulz, I. (1996). ATP regulates calcium leak from agonist-sensitive internal calcium stores. FASEB J, 10(2), 302-308. doi:10.1096/fasebj.10.2.8641563
  • Hofer, A. M., Schlue, W. R., Curci, S., & Machen, T. E. (1995). Spatial distribution and quantitation of free luminal [Ca] within the InsP3-sensitive internal store of individual BHK-21 cells: ion dependence of InsP3-induced Ca release and reloading. FASEB J, 9(9), 788-798. doi:10.1096/fasebj.9.9.7601343
  • Hofer, A. M., & Machen, T. E. (1994). Direct measurement of free Ca in organelles of gastric epithelial cells. Am J Physiol, 267(3 Pt 1), G442-451. doi:10.1152/ajpgi.1994.267.3.G442
  • Hofer, A. M., & Machen, T. E. (1993). Technique for in situ measurement of calcium in intracellular inositol 1,4,5-trisphosphate-sensitive stores using the fluorescent indicator mag-fura-2. Proc Natl Acad Sci U S A, 90(7), 2598-2602. doi:10.1073/pnas.90.7.2598
  • Hofer, A. M., & Machen, T. E. (1992). K-induced alkalinization in all cell types of rabbit gastric glands: a novel K/H exchange mechanism. J Membr Biol, 126(3), 245-256. doi:10.1007/bf00232321

Online Lecture Series

Hofer, A.M. (2012) Henry Stewart Talks: “Extracellular Calcium Signaling”, in Simpson, A. (ed.), Calcium Signaling I: Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.

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